You can utilize CloudLinux Selector to enable ionCube Loader in Plesk. Follow these steps:
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Sign in to your Plesk account.
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On the right-hand sidebar, click on "PHP Selector."
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Select the "Extensions" menu.
Note: If the Extensions page displays an error related to the native PHP version, switch it to a non-native version initially.
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Check the box for "ioncube_loader." Once enabled, a success message will be displayed.
The message will indicate that the ionCube Loader module has been saved.